With the Vitaphone Racing and with his team-mate Michael Bartels, Bertolini had a triumphant season in 2006: he was GT champion with three wins, including one in the legendary Spa-Francorchamps 24 Hours, as well as taking two seconds and scoring points in all ten rounds. In 2008, he was again paired with Bartels and again won the championship with a further Spa-Francorchamps win. Still team-mates with the German, in 2009 the winning streak continued with victories in Budapest and Adria and a third drivers’ title. In 2010, sticking to the idea that you don’t change a winning team, Andrea and Bartels were crowned world champions. In 2013 he took the Asian Le Mans Series crown while the following year he won once again the Spa-Francorchamps 24 Hours, as well as the European Le Mans Series title at the wheel of the SMP Racing 458 Italia, alongside Russian drivers Sergey Zlobin and Victor Shaytar.
In 2015 he clinched his eighth title winning the World Endurance Championship in the GTE-Am class with the No. 72 Ferrari of SMP Racing with Shaytar and Aleksey Basov. For the crew three wins during the season at the Nurburgring, the Circuit of the Americas and, above all, the 24 Hours of Le Mans. In 2016 he was closed to win the European Le Mans Series, a championship in which he took part also in 2017 and 2018 together with the Blancpain Endurance Cup. In 2019, Bertolini secured the Blancpain GT World Challenge title with Louis Machiels at the wheel of the 488 GT3 of AF Corse. Bertolini came close to taking the Sprint Cup title in 2020, ending the season runner-up.
In 2021, the year when Andrea Bertolini reached (and surpassed) 500 F1 single-seater tests, the driver from Sassuolo contested his sixth season in the GT World Challenge, in the Sprint and the Endurance Cup, alongside Louis Machiels. Bertolini missed out on a tenth international title by a hair’s breadth. However, he still claimed plenty of wins, like the last round of the season at Valencia and numerous placings that brought him third place in the Pro-Am class of the Sprint Cup. In 2022, the Italian will continue to chase glory in the GT World Challenge Europe, both in the Sprint and Endurance Cup.